Multi-targeted science for progressive hair loss
Multi-targeted science for progressive hair loss
Engineered for the complex systems biology of hair follicles, using targeted natural ingredients.
Engineered for the complex systems biology of hair follicles, using targeted natural ingredients.
Multi-targeted science for progressive hair loss
This pharmaceutical-grade complex blends high-potency extraction with food-derived safety, setting a new benchmark for bioavailable purity.
This pharmaceutical-grade complex blends high-potency extraction with food-derived safety, setting a new benchmark for bioavailable purity.
This pharmaceutical-grade complex blends high-potency extraction with food-derived safety, setting a new benchmark for bioavailable purity.
Clinical Studies & Evidence
Science that speaks for itself
Our verified research portfolio combines randomized controlled trials with peer-reviewed evidence, providing concrete validation for our formula’s clinical efficacy.
Study 1: In a six-month randomised, placebo-controlled clinical trial of 60 participants
Ingredients in TOPK11 improved hair density at parting region by retrospective assessment versus placebo. The study also showed a significant (p<0.045) improvement in photographic hair density parameters from image analysis.
Full Sample Analysis: 60 participants equally comprising men and women were randomised to placebo (1/3 of volunteers of each sex) or treatment group (2/3 of volunteers of each sex) and ingested capsules for 6 months and were examined photographically and given questionnaires. Source: Schulz et al. Fenugreek+ micronutrients: Efficacy of a food supplement against hair loss. Kosmetische Medizin. 2006;27(4):176-9.
Study 2
Study 3
Study 4
Study 1: In a six-month randomised, placebo-controlled clinical trial of 60 participants
Ingredients in TOPK11 improved hair density at parting region by retrospective assessment versus placebo. The study also showed a significant (p<0.045) improvement in photographic hair density parameters from image analysis.
Full Sample Analysis: 60 participants equally comprising men and women were randomised to placebo (1/3 of volunteers of each sex) or treatment group (2/3 of volunteers of each sex) and ingested capsules for 6 months and were examined photographically and given questionnaires. Source: Schulz et al. Fenugreek+ micronutrients: Efficacy of a food supplement against hair loss. Kosmetische Medizin. 2006;27(4):176-9.
Study 2
Study 3
Study 4
Apple Extract - Unmatched scientific evidence
Procyanindin B2
The most potent B-type procyanidin for hair growth.
Mechanism of Action
Counters TGF-β-induced telogen, elongating anagen
Best Practices for Formulations
Oral administration in gastric-resistant capsules, at 400mg BID. Pharmacokinetic enhancer (e.g. piperine) is recommended.
Study Citation
Participants, Duration & Design
Dose & Administration Route
Efficacy Outcomes
Safety, Adverse Events & Notes
De Biasio 2023; Yeniay 2022; Tenore 2018; Takahashi 2005; Takahashi 2001
442 adults; 2–6-month double-blind randomised controlled trials
400 mg BID (Procyanidin B2-enriched) or topical 0.7–1% BID
Topical: +13.8 to +24.8 hairs/cm² vs placebo (p<0.001); Oral: +14 to +19.2 hairs/cm² (significant); consistent gains across studies
Excellent tolerability; no serious AEs; occasional mild local scaling/itching with topical
Procyanindin B2
The most potent B-type procyanidin for hair growth.
Mechanism of Action
Counters TGF-β-induced telogen, elongating anagen
Best Practices for Formulations
Oral administration in gastric-resistant capsules. Pharmacokinetic enhancer (e.g. piperine) is recommended.
Study Citation
Participants, Duration & Design
Dose & Administration Route
Efficacy Outcomes
Safety, Adverse Events & Notes
De Biasio 2023; Yeniay 2022; Tenore 2018; Takahashi 2005; Takahashi 2001
442 adults; 2–6-month double-blind randomised controlled trials
400 mg BID (Procyanidin B2-enriched) or topical 0.7–1% BID
Topical: +13.8 to +24.8 hairs/cm² vs placebo (p<0.001); Oral: +14 to +19.2 hairs/cm² (significant); consistent gains across studies
Excellent tolerability; no serious AEs; occasional mild local scaling/itching with topical
Procyanindin B2
The most potent B-type procyanidin for hair growth.
Mechanism of Action
Counters TGF-β-induced telogen, elongating anagen
Best Practices for Formulations
Oral administration in gastric-resistant capsules. Pharmacokinetic enhancer (e.g. piperine) is recommended.
De Biasio 2023; Yeniay 2022; Tenore 2018; Takahashi 2005; Takahashi 2001
442 adults; 2–6-month double-blind randomised controlled trials
400 mg BID (Procyanidin B2-enriched) or topical 0.7–1% BID
Topical: +13.8 to +24.8 hairs/cm² vs placebo (p<0.001); Oral: +14 to +19.2 hairs/cm² (significant); consistent gains across studies
Excellent tolerability; no serious AEs; occasional mild local scaling/itching with topical
Working Mechanism
How TOPK11 transforms your hair health
How TOPK11 transforms your hair health
TOPK11 employs a scientifically validated, multi-modal approach to combat hereditary hair loss. By directly addressing the root causes at a cellular level, it safely and effectively restores your natural hair growth cycle.
TOPK11 employs a scientifically validated, multi-modal approach to combat hereditary hair loss. By directly addressing the root causes at a cellular level, it safely and effectively restores your natural hair growth cycle.
Reduce Shedding
TOPK11 actively blocks DHT and TGF-Beta production, halting follicle miniaturization and minimizing premature hair fall without causing any harmful hormonal side effects.
Stimulate Regrowth
By improving blood circulation and deeply nourishing the scalp, it directly revitalizes dormant follicles, encouraging the rapid emergence of new, healthy, and denser hair.
Extend Growth Phase
Potent ingredients like Procyanidin B2 target oxidative stress and mitochondrial function, prolonging the active anagen phase to ensure stronger, longer, and more resilient hair.
Active Ingredients
Engineered for the complexity of hair biology
This pharmaceutical-grade complex blends high-potency extraction with food-derived safety, setting a new standard for nutraceuticals.
Apple Extract
60% Polyphenols including procyanidin B2
Apple Extract
60% Polyphenols including procyanidin B2
Fenugreek Extract
50% Saponins
Fenugreek Extract
50% Saponins
Magnesium Amino Acid Chelate
Elemental magnesium
Magnesium Amino Acid Chelate
Elemental magnesium
Haematococcus pluvialis Powder
Astaxanthin
Haematococcus pluvialis Powder
Astaxanthin
Soybean Extract
40% Isoflavones
Soybean Extract
40% Isoflavones
Iron Amino Acid Chelate
Elemental iron
Iron Amino Acid Chelate
Elemental iron
Vitamin E
DL-alpha Tocopheryl Acetate
Vitamin E
DL-alpha Tocopheryl Acetate
Black Pepper Extract
95% Piperine
Black Pepper Extract
95% Piperine
Mechanisms of Action
The engine behind your growth
We target the four biological pathways that drive hair loss and follicular miniaturization. From balancing hormones to protecting mitochondria, we re-engineer your growth cycle from the inside out.
Mechanisms of Action
Hormones
Dihydrotestosterone (DHT) can help miniaturise the hair follicle to shrink and eventually close entirely in long-term genetic hair loss.
Mechanisms of Action
Signalling
TGF-beta is a signalling protein that may be critical to contributing to the miniaturisation according to multiple research publications.
Mechanisms of Action
Metabolism
Energy metabolism is often disregulated and associated with poor hair outcomes in several published research papers
Mechanisms of Action
Cell damage
Dysregulated metabolism causes harmful byproducts like free radicals and reactive oxygen species that harm mitochonria inside cells.
Mechanisms of Action
Hormones
Dihydrotestosterone (DHT) can help miniaturise the hair follicle to shrink and eventually close entirely in long-term genetic hair loss.
Mechanisms of Action
Signalling
TGF-beta is a signalling protein that may be critical to contributing to the miniaturisation according to multiple research publications.
Mechanisms of Action
Metabolism
Energy metabolism is often disregulated and associated with poor hair outcomes in several published research papers
Mechanisms of Action
Cell damage
Dysregulated metabolism causes harmful byproducts like free radicals and reactive oxygen species that harm mitochonria inside cells.
Mechanisms of Action
Hormones
Dihydrotestosterone (DHT) can help miniaturise the hair follicle to shrink and eventually close entirely in long-term genetic hair loss.
Mechanisms of Action
Signalling
TGF-beta is a signalling protein that may be critical to contributing to the miniaturisation according to multiple research publications.
Mechanisms of Action
Metabolism
Energy metabolism is often disregulated and associated with poor hair outcomes in several published research papers
Mechanisms of Action
Cell damage
Dysregulated metabolism causes harmful byproducts like free radicals and reactive oxygen species that harm mitochonria inside cells.
Mechanisms of Action
Hormones
Dihydrotestosterone (DHT) can help miniaturise the hair follicle to shrink and eventually close entirely in long-term genetic hair loss.
Mechanisms of Action
Signalling
TGF-beta is a signalling protein that may be critical to contributing to the miniaturisation according to multiple research publications.
Mechanisms of Action
Metabolism
Energy metabolism is often disregulated and associated with poor hair outcomes in several published research papers
Mechanisms of Action
Cell damage
Dysregulated metabolism causes harmful byproducts like free radicals and reactive oxygen species that harm mitochonria inside cells.
Mechanisms of Action
Hormones
Dihydrotestosterone (DHT) can help miniaturise the hair follicle to shrink and eventually close entirely in long-term genetic hair loss.
Mechanisms of Action
Signalling
TGF-beta is a signalling protein that may be critical to contributing to the miniaturisation according to multiple research publications.
Mechanisms of Action
Metabolism
Energy metabolism is often disregulated and associated with poor hair outcomes in several published research papers
Mechanisms of Action
Cell damage
Dysregulated metabolism causes harmful byproducts like free radicals and reactive oxygen species that harm mitochonria inside cells.
Mechanisms of Action
Hormones
Dihydrotestosterone (DHT) can help miniaturise the hair follicle to shrink and eventually close entirely in long-term genetic hair loss.
Mechanisms of Action
Signalling
TGF-beta is a signalling protein that may be critical to contributing to the miniaturisation according to multiple research publications.
Mechanisms of Action
Metabolism
Energy metabolism is often disregulated and associated with poor hair outcomes in several published research papers
Mechanisms of Action
Cell damage
Dysregulated metabolism causes harmful byproducts like free radicals and reactive oxygen species that harm mitochonria inside cells.
Mechanisms of Action
Hormones
Dihydrotestosterone (DHT) can help miniaturise the hair follicle to shrink and eventually close entirely in long-term genetic hair loss.
Mechanisms of Action
Signalling
TGF-beta is a signalling protein that may be critical to contributing to the miniaturisation according to multiple research publications.
Mechanisms of Action
Metabolism
Energy metabolism is often disregulated and associated with poor hair outcomes in several published research papers
Mechanisms of Action
Cell damage
Dysregulated metabolism causes harmful byproducts like free radicals and reactive oxygen species that harm mitochonria inside cells.
Mechanisms of Action
Hormones
Dihydrotestosterone (DHT) can help miniaturise the hair follicle to shrink and eventually close entirely in long-term genetic hair loss.
Mechanisms of Action
Signalling
TGF-beta is a signalling protein that may be critical to contributing to the miniaturisation according to multiple research publications.
Mechanisms of Action
Metabolism
Energy metabolism is often disregulated and associated with poor hair outcomes in several published research papers
Mechanisms of Action
Cell damage
Dysregulated metabolism causes harmful byproducts like free radicals and reactive oxygen species that harm mitochonria inside cells.
Mechanisms of Action
Hormones
Dihydrotestosterone (DHT) can help miniaturise the hair follicle to shrink and eventually close entirely in long-term genetic hair loss.
Mechanisms of Action
Signalling
TGF-beta is a signalling protein that may be critical to contributing to the miniaturisation according to multiple research publications.
Mechanisms of Action
Metabolism
Energy metabolism is often disregulated and associated with poor hair outcomes in several published research papers
Mechanisms of Action
Cell damage
Dysregulated metabolism causes harmful byproducts like free radicals and reactive oxygen species that harm mitochonria inside cells.
Mechanisms of Action
Hormones
Dihydrotestosterone (DHT) can help miniaturise the hair follicle to shrink and eventually close entirely in long-term genetic hair loss.
Mechanisms of Action
Signalling
TGF-beta is a signalling protein that may be critical to contributing to the miniaturisation according to multiple research publications.
Mechanisms of Action
Metabolism
Energy metabolism is often disregulated and associated with poor hair outcomes in several published research papers
Mechanisms of Action
Cell damage
Dysregulated metabolism causes harmful byproducts like free radicals and reactive oxygen species that harm mitochonria inside cells.
Mechanisms of Action
Hormones
Dihydrotestosterone (DHT) can help miniaturise the hair follicle to shrink and eventually close entirely in long-term genetic hair loss.
Mechanisms of Action
Signalling
TGF-beta is a signalling protein that may be critical to contributing to the miniaturisation according to multiple research publications.
Mechanisms of Action
Metabolism
Energy metabolism is often disregulated and associated with poor hair outcomes in several published research papers
Mechanisms of Action
Cell damage
Dysregulated metabolism causes harmful byproducts like free radicals and reactive oxygen species that harm mitochonria inside cells.
Mechanisms of Action
Hormones
Dihydrotestosterone (DHT) can help miniaturise the hair follicle to shrink and eventually close entirely in long-term genetic hair loss.
Mechanisms of Action
Signalling
TGF-beta is a signalling protein that may be critical to contributing to the miniaturisation according to multiple research publications.
Mechanisms of Action
Metabolism
Energy metabolism is often disregulated and associated with poor hair outcomes in several published research papers
Mechanisms of Action
Cell damage
Dysregulated metabolism causes harmful byproducts like free radicals and reactive oxygen species that harm mitochonria inside cells.
Mechanisms of Action
Hormones
Dihydrotestosterone (DHT) can help miniaturise the hair follicle to shrink and eventually close entirely in long-term genetic hair loss.
Mechanisms of Action
Signalling
TGF-beta is a signalling protein that may be critical to contributing to the miniaturisation according to multiple research publications.
Mechanisms of Action
Metabolism
Energy metabolism is often disregulated and associated with poor hair outcomes in several published research papers
Mechanisms of Action
Cell damage
Dysregulated metabolism causes harmful byproducts like free radicals and reactive oxygen species that harm mitochonria inside cells.
Mechanisms of Action
Hormones
Dihydrotestosterone (DHT) can help miniaturise the hair follicle to shrink and eventually close entirely in long-term genetic hair loss.
Mechanisms of Action
Signalling
TGF-beta is a signalling protein that may be critical to contributing to the miniaturisation according to multiple research publications.
Mechanisms of Action
Metabolism
Energy metabolism is often disregulated and associated with poor hair outcomes in several published research papers
Mechanisms of Action
Cell damage
Dysregulated metabolism causes harmful byproducts like free radicals and reactive oxygen species that harm mitochonria inside cells.
Mechanisms of Action
Hormones
Dihydrotestosterone (DHT) can help miniaturise the hair follicle to shrink and eventually close entirely in long-term genetic hair loss.
Mechanisms of Action
Signalling
TGF-beta is a signalling protein that may be critical to contributing to the miniaturisation according to multiple research publications.
Mechanisms of Action
Metabolism
Energy metabolism is often disregulated and associated with poor hair outcomes in several published research papers
Mechanisms of Action
Cell damage
Dysregulated metabolism causes harmful byproducts like free radicals and reactive oxygen species that harm mitochonria inside cells.
Mechanisms of Action
Hormones
Dihydrotestosterone (DHT) can help miniaturise the hair follicle to shrink and eventually close entirely in long-term genetic hair loss.
Mechanisms of Action
Signalling
TGF-beta is a signalling protein that may be critical to contributing to the miniaturisation according to multiple research publications.
Mechanisms of Action
Metabolism
Energy metabolism is often disregulated and associated with poor hair outcomes in several published research papers
Mechanisms of Action
Cell damage
Dysregulated metabolism causes harmful byproducts like free radicals and reactive oxygen species that harm mitochonria inside cells.
Safety & Quality
Quality by design,
never by accident.
We refuse to cut corners. Your well-being is our priority, which is why we demand the same uncompromising standards for your body as you do.
01
Gold-Standard Evidence
Formulated with active ingredients rigorously validated by randomized controlled trials to ensure scientifically proven efficacy and reliable results.
02
Expert Collaboration
03
Transparent Dosing
04
Premium Sourcing
05
Gentle Formulation
06
Regulatory Compliance
01
Gold-Standard Evidence
Formulated with active ingredients rigorously validated by randomized controlled trials to ensure scientifically proven efficacy and reliable results.
02
Expert Collaboration
03
Transparent Dosing
04
Premium Sourcing
05
Gentle Formulation
06
Regulatory Compliance
01
Gold-Standard Evidence
Formulated with active ingredients rigorously validated by randomized controlled trials to ensure scientifically proven efficacy and reliable results.
02
Expert Collaboration
03
Transparent Dosing
04
Premium Sourcing
05
Gentle Formulation
06
Regulatory Compliance
Innovation & Development
TOPK11 - Developed by top 2% published scientists
Recognized by Stanford University as a top 2% published scientist in medicinal and biomolecular chemistry (2023 and 2024), Systems Trichology co-founder, Dr. Nicholas J. Sadgrove, is a pioneer in hair loss research and nutraceutical innovation.
An Updated Etiology of Hair Loss and the New Cosmeceutical Paradigm in Therapy: Clearing ‘the Big Eight Strikes’.
The ‘bald’ phenotype (androgenetic alopecia) is caused by the high glycaemic, high cholesterol and low mineral ‘western diet’.
The new paradigm for androgenetic alopecia and plant-based folk remedies: 5α-reductase inhibition, reversal of secondary microinflammation and improving insulin resistance.
Honest nutraceuticals, cosmetics, therapies, and foods (NCTFs): Standardization and safety of natural products.
